Heat Shock Response
Gene co-expression module in CD4⁺ T cells
| Category | Stress |
|---|---|
| Genes | 21 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 21 genes have a known function matching the annotation |
Why this annotation
Unambiguous heat-shock protein / chaperone module: HSPH1, HSP90AA1, HSPA1A, HSPA1B, HSPE1, HSP90AB1, DNAJA1/A4/B1/B4, HSPD1, HSPA8, TCP1, CHORDC1, ZFAND2A, UBB. Classic heat-shock/proteotoxic stress response, neighbor to UPR/ISR modules. Strong coherence.
Genes
ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18, NABP1, TCP1, TRA2B, UBB, ZFAND2A
Most correlated modules
- Heat-shock response · correlation 0.81
- mRNA Splicing Factors · correlation 0.62
- Cytokine receptor signaling · correlation 0.59
- Immediate Early AP-1 · correlation 0.59
- Pol II Transcription Regulation · correlation 0.57
- Integrated Stress Response · correlation 0.53
- Glucocorticoid Immunoregulation · correlation 0.51
- Unfolded Protein Response · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.