Inflammatory effector
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 18 genes have a known function matching the annotation |
Why this annotation
Mix of myeloid/innate immune genes (NCF4 - NADPH oxidase, C3AR1 - complement receptor, CMTM3) with the Th-relevant cytokine receptor IL18R1, and cytoskeletal/membrane genes (SYNE2, EPB41, RHOC, CLDND1). IL18R1, C3AR1, NCF4 are inflammation-associated. The module is inflammation-upregulated in IBD (strong CD delta). The presence of IL18R1 (marks inflammatory/Th1-Th17 effector CD4 T cells) alongside innate-immune genes suggests an inflammatory effector state. STN1 (telomere) is the top hub but not thematic. Mixed; immune regulation/inflammatory effector best fit.
Genes
C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1, IL18R1, MOSPD3, NCF4, PHKB, PPP2R2B, RGL4, RHOC, STK10, STN1, SYNE2
Most correlated modules
- Inflammatory activation · correlation 0.79
- Rho-GTPase Migration · correlation 0.72
- DNA repair/replication · correlation 0.70
- Interferon response · correlation 0.67
- Chemokine Migration · correlation 0.65
- IL10/cytokine signaling · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.