Activated Treg
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Strong, coherent module with classic activated Treg/effector signature: CTLA4, IL2RA (CD25), TNFRSF18 (GITR), TNFRSF4 (OX40), TNFRSF1B, BATF, plus interferon-induced GBP2. This is the canonical activated/regulatory CD4 T-cell costimulatory/inhibitory receptor program, strongly inflammation-associated and reversed in remission. Clear immune regulation/Treg activation module.
Genes
ATP5MC1, BATF, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2, NINJ2, TNFRSF18, TNFRSF1B, TNFRSF4, TRAF3, TXNDC17, TYMP
Most correlated modules
- TNF activation survival · correlation 0.89
- Activated effector Tcell · correlation 0.89
- MAPK feedback signaling · correlation 0.88
- Regulatory T cell · correlation 0.85
- Th1 IL12 response · correlation 0.85
- mRNA stability regulation · correlation 0.84
- NF-kB feedback · correlation 0.83
- Proteasome translation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.