GIMAP survival
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 25 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 25 genes have a known function matching the annotation |
Why this annotation
Dominated by the GIMAP gene family (GIMAP7, GIMAP5, GIMAP4, GIMAP8, GIMAP1) — GTPases of immunity-associated proteins essential for T cell survival/homeostasis. Plus P2RY8, ARL4C, ABLIM1. GIMAPs are markers of resting/naive T cell survival. This module is a clear GIMAP/T cell survival signature, positively associated with inflammation in both UC and CD.
Genes
ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN, DYNLT1, EPHA4, ESYT2, GIMAP1, GIMAP4, GIMAP5, GIMAP7, GIMAP8, GLIPR1, HECA, MAN1C1, P2RY8, PDE3B, PRMT2, SNRK, SUN2, ZNF131
Most correlated modules
- TGF-beta response · correlation 0.64
- TCR signaling · correlation 0.61
- Naive T cell · correlation 0.52
- Naive T quiescence · correlation 0.49
- T cell signaling · correlation 0.49
- Ribosomal proteins · correlation 0.48
- Resting memory T cell · correlation 0.45
- Post-transcriptional regulation · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.