Oxidative Phosphorylation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include OxPhos/ETC components (ATP5MC2, NDUFB5, SLC25A6, COX7C, UQCRH), redox enzymes (PRDX2, GPX4), translation initiation (EIF3H, EIF3M), and chromatin/housekeeping factors (ANP32B, HINT1, NSA2). The dominant coherent functional signal is mitochondrial energy metabolism plus antioxidant defense (GPX4, PRDX2), with LAT being the only clear T cell signaling gene. This closely parallels neighbor M90 with shared OxPhos genes, supporting a metabolic energy/respiration program. Uniform expression and housekeeping nature with ETC dominance makes OxPhos the best label.
Genes
ANP32B, ATP5MC2, C19orf53, COX7C, EIF3H, EIF3M, EMC7, GPX4, HINT1, LAT, NDUFB5, NSA2, PRDX2, SIAH2, SLC25A6, SSU72, TRIR, UQCRH, YWHAB
Most correlated modules
- Oxidative Phosphorylation · correlation 0.77
- T cell activation · correlation 0.76
- Translation machinery · correlation 0.73
- Protein/ER secretory machinery · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.