Vesicular trafficking
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 26 genes have a known function matching the annotation |
Why this annotation
Mixed module of vesicular trafficking (ARL8B, GGA2, BLOC1S2, PLEKHA3), signaling adaptors (SLA2, MARK3, INPP4A), chromatin (KDM5C), proteasome (PSMD6), RNA processing (PHAX, POLR2J), and mitochondrial import (TIMM8B). No single dominant program; broadly intracellular trafficking/housekeeping with uniform low expression. DTX3L (interferon-related) present. Best characterized as general housekeeping/trafficking.
Genes
ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3, INPP4A, KDM5C, MAP7D1, MARK3, NCBP2, NFATC3, NUCB1, PHAX, PLEKHA3, POLR2J, PSMD6, RNPS1, RTF1, SLA2, SMNDC1, STMP1, TIMM8B, TMEM208
Most correlated modules
- Chromatin Regulation · correlation 0.92
- PD-L1 checkpoint · correlation 0.80
- Glycosylation & trafficking · correlation 0.80
- Oxidative phosphorylation · correlation 0.79
- Epigenetic regulation · correlation 0.76
- Respiratory chain assembly · correlation 0.75
- Protein/ER secretory machinery · correlation 0.75
- Chaperone Proteostasis · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.