Cell cycle regulators
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
Mixed set of housekeeping/cell-regulatory genes: SH3GLB1 (Bif-1, autophagy), CCNDBP1 (cyclin D binding), EAPP (E2F-associated), RBBP4 (chromatin/histone chaperone), CFAP20, LAPTM4A. IFNAR2 is the type I interferon receptor. No single dominant program; weak inflammatory signal. The presence of RBBP4, EAPP, CCNDBP1 leans toward cell-cycle/chromatin regulation but coherence is diffuse. Given IFNAR2 and inflammation association, but mostly generic regulators, best classed as a proliferation/chromatin regulatory module.
Genes
CCDC28A, CCNDBP1, CFAP20, EAPP, IFNAR2, LAPTM4A, RBBP4, SH3GLB1
Most correlated modules
- mRNA stability regulation · correlation 0.88
- MAPK feedback signaling · correlation 0.88
- NF-kB feedback · correlation 0.83
- Activated effector Tcell · correlation 0.82
- Actomyosin signaling · correlation 0.81
- mRNA splicing · correlation 0.81
- Inflammatory activation · correlation 0.80
- Mitochondrial OxPhos · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.