Proteasome/translation
Gene co-expression module in CD4⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Strong, coherent module dominated by proteasome subunits (PSMB6, PSMD11, PSMA2), RANBP1 (nuclear transport), translation factors (EIF5B, EIF4E, CDC123), and metabolic/OxPhos genes (PKM, UQCRFS1, MRPL20, SLIRP). The clear proteasome core plus translation machinery indicates a protein-synthesis/degradation/turnover program characteristic of activated, metabolically active T cells. Inflammation-correlated and treatment-reversible.
Genes
ANP32E, CDC123, EIF4E, EIF5B, EMC8, MRPL20, NME7, PDXK, PKM, PRPF31, PSMA2, PSMB6, PSMD11, RANBP1, SEC11C, SLIRP, SUMO4, UQCRFS1
Most correlated modules
- RNA processing splicing · correlation 0.95
- T-cell activation · correlation 0.89
- Cellular biosynthesis · correlation 0.89
- NF-kB regulation · correlation 0.88
- Proteostasis OxPhos · correlation 0.87
- Membrane trafficking · correlation 0.82
- ER-Golgi Trafficking · correlation 0.76
- TNF activation survival · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.