TNF/NF-kB activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include several NF-kB target and TNF-induced genes: BIRC3 and TRAF1 are canonical NF-kB-driven anti-apoptotic mediators, SQSTM1/p62 links NF-kB and autophagy, PMAIP1 (NOXA) and SERPINB9 are activation/apoptosis-regulatory genes. SDC4, SLC7A5 (amino acid transporter for activated T cells), DUSP10 (MAPK phosphatase, T-cell activation regulator), and SAT1 reflect an activated/stress-responsive T-cell state. The module is positively associated with CD inflammation, consistent with TNF/NF-kB activation signaling rather than artifact. Combined IEG/activation flavor with NF-kB hubs places it in the TCR/AP1/NFkB pathway, with metabolic activation features. No lineage contamination (uniform).
Genes
BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1, RBBP8, SAT1, SDC4, SERPINB9, SLC7A5, SQSTM1, TRAF1
Most correlated modules
- NF-kB activation · correlation 0.65
- Activated Treg · correlation 0.64
- Chemokine Migration · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.