Oxidative phosphorylation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 21 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Dominated by mitochondrial oxidative phosphorylation and proteasome genes: NDUFA8 (Complex I), PRDX3 (mito peroxiredoxin), ETFA/ACADVL (fatty acid oxidation), COX14 (Complex IV assembly), TIMMDC1 (Complex I assembly), NDUF, plus proteasome PSMC2/PSMD2. Clear oxidative metabolism module.
Genes
ACADVL, CHMP1A, COX14, EIF2AK1, EML2, ETFA, GPR108, NDUFA8, PARP1, PRDX3, PSMC2, PSMD2, RNF5, RPN2, RRP36, STAMBP, TIMMDC1, TMEM14B, TMEM183A, TRAPPC3, VPS25
Most correlated modules
- PD-L1 checkpoint · correlation 0.95
- Respiratory chain assembly · correlation 0.94
- Glycosylation & trafficking · correlation 0.94
- Epigenetic regulation · correlation 0.90
- Oxidative Phosphorylation · correlation 0.87
- RNA & Chromatin Regulation · correlation 0.84
- Effector Immune Activation · correlation 0.82
- Chromatin regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.