mRNA splicing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Strongly enriched for mRNA splicing and RNA processing factors: LUC7L3, U2SURP, SON, DDX46, LSM14A, SUGP2, SRRM1, plus chaperones (DNAJC7, ST13, HSPA4) and splicing-associated genes. The dominant coherent theme is spliceosome/RNA processing, a transcriptional/post-transcriptional program upregulated with inflammation.
Genes
ANAPC5, C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LSM14A, LUC7L3, MRPL47, RGS10, SON, SRRM1, ST13, SUGP2, TAF11, U2SURP, UBE2F
Most correlated modules
- Actomyosin signaling · correlation 0.86
- Mitochondrial OxPhos · correlation 0.84
- Cell cycle regulators · correlation 0.81
- Interferon-stimulated genes · correlation 0.78
- Transcription/RNA processing · correlation 0.77
- mRNA stability regulation · correlation 0.74
- ER protein processing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.