Post-transcriptional regulation
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 30 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes are predominantly RNA-binding and regulatory factors: TNRC6B (miRNA silencing/GW182), TTC14, RBM39, TUT4 (RNA uridylation), NKTR, DDX39B (mRNA export), CHD2 (chromatin). Mixed with T cell signaling adaptors TRAF3IP3, FYB1, TBC1D10C, EVI2B and the lineage factor BCL11B. The dominant coherent theme of the hubs is RNA processing/post-transcriptional regulation. Inflammation-upregulated in IBD. Uniform expression, moderate coherence suggests a broad nuclear regulatory program rather than contamination.
Genes
BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B, FAM78A, FRYL, FYB1, GNB5, HERC4, MDM4, MED13L, NKTR, NMT2, PCM1, PNRC1, RAPGEF6, RBM25, RBM39, SLFN5, SYNRG, TBC1D10C, TNRC6B, TP53BP1, TRAF3IP3, TTC14, TUT4
Most correlated modules
- Transcription/RNA processing · correlation 0.76
- DNA repair/replication · correlation 0.70
- Integrin adhesion · correlation 0.69
- TCR signaling activation · correlation 0.60
- Immune regulation · correlation 0.59
- Leukocyte adhesion signaling · correlation 0.53
- Tfh program · correlation 0.47
- Interferon response · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.