mRNA Stability/Processing
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
YBX1 (Y-box binding protein 1) is a multifunctional RNA-binding protein involved in mRNA translation, stability, and stress responses. NAP1L1 is a nucleosome assembly protein involved in chromatin remodeling and cell proliferation. NHP2 is an H/ACA snoRNP component involved in rRNA processing. HNRNPA0 is a heterogeneous nuclear ribonucleoprotein involved in mRNA processing and stability. C19orf53 (also known as LRRC59-related) is associated with ribosome biogenesis. EDF1 (elongation factor for RNA Pol II) supports transcription elongation. GPX4 is a glutathione peroxidase protecting against ferroptosis/oxidative stress. PTMA (prothymosin alpha) is a chromatin remodeling protein. IMPDH2 is a rate-limiting enzyme in guanine nucleotide biosynthesis. Overall, this module captures a general RNA processing/mRNA stability and nucleotide biosynthesis housekeeping program, with YBX1 and HNRNPA0 as RNA-binding hubs. Neighbors (M9 glycolysis, M10 OxPhos) suggest this is part of a broader metabolic-housekeeping neighborhood, consistent with a proliferative/biosynthetic support program.
Genes
C19orf53, EDF1, GPX4, HNRNPA0, IMPDH2, NAP1L1, NHP2, PTMA, YBX1
Most correlated modules
- Mitochondrial Metabolism · correlation 0.93
- Glycolysis Program · correlation 0.92
- Mitochondrial ETC/OxPhos · correlation 0.91
- Histone Synthesis S-phase · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.