Histone Synthesis S-phase
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
SLBP (stem-loop binding protein, histone mRNA processing linked to S-phase), RMI2 (Fanconi/BLM complex, DNA repair during replication), CDK2 (cyclin-dependent kinase 2, central S-phase kinase), HAT1 (histone acetyltransferase, newly synthesized histone H4 acetylation during replication), HPRT1 (purine salvage, nucleotide biosynthesis), HNRNPF (RNA processing), TMEM109 (ER membrane, S-phase associated), EIF4EBP1 (translational control), PAQR4 (membrane receptor). The core signature of SLBP+CDK2+HAT1+RMI2 defines histone biosynthesis coupled to DNA replication and S-phase CDK activity. Neighbor context: consistent with the S-phase cluster, here emphasizing histone supply and CDK2 activity.
Genes
CDK2, EIF4EBP1, HAT1, HNRNPF, HPRT1, PAQR4, RMI2, SLBP, TMEM109
Most correlated modules
- DNA Replication Fork · correlation 0.95
- Cellular Housekeeping · correlation 0.94
- S-phase Progression · correlation 0.93
- MCM Helicase Loading · correlation 0.92
- Replication Licensing · correlation 0.92
- Mitochondrial Metabolism · correlation 0.90
- Replication Stress Checkpoint · correlation 0.89
- RNA & Redox Housekeeping · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.