SCUBA

PTMA — Prothymosin alpha

PTMA belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PTMA's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsIntegrated Stress Response
Stress		CYCS, DDIT3, EIF1, EIF4A3, GTF2B, IFRD1, NASP, TUBA1AView in SCUBA
CD8⁺ T cellsmRNA Stability/Processing
RNA processing & translation		C19orf53, EDF1, GPX4, HNRNPA0, IMPDH2, NAP1L1, NHP2, YBX1View in SCUBA
EnterocytesNucleolar RNA-binding
RNA processing & translation		HMGB1, HMGN2, HNRNPA1, HNRNPA2B1, HNRNPA3, HSP90AA1, HSP90AB1, NCL +2 moreView in SCUBA
Gamma-delta T cellsG1/S Entry
Cell cycle		CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more
Goblet cellsChromatin Organization
chromatin regulation & transcription		CBX3, HMGB1, HMGB3, HMGN1, HNRNPA2B1, STMN1, TPRKBView in SCUBA
Innate lymphoid cellsMitochondrial Housekeeping
Mitochondrial & OxPhos		COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 moreView in SCUBA
Lymphatic endothelialTranslation Elongation
RNA processing & translation		ANXA2, EEF1A1, EEF2, EIF1, FTH1, FTL, HNRNPA0, HNRNPA1 +2 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos		ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 moreView in SCUBA
Mucosal-associated invariant T cellER Stress UPR
Stress		DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA +9 more
Natural Killer cellsMetabolic Activation
Metabolism		FABP5, LDHA, NCL, NOP56, POMP, SERBP1, SLC25A3, SNRPG +2 moreView in SCUBA
NeutrophilsTranslation Initiation
Housekeeping		EIF1AX, EIF3A, HNRNPA1, NAP1L1, NCL, PPIA, RPN2, SET +1 more
Smooth muscle cellsTranslation elongation housekeeping
Housekeeping		COX4I1, EEF1A1, EEF1D, EEF2, FTH1, FTL, GAPDH, RACK1 +4 moreView in SCUBA

About the gene

SynonymsTMSA
Chromosome2: 231706895-231713551
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins

Function

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.