Glycolysis Program
Gene co-expression module in CD8⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
The top hub genes PGAM1 (phosphoglycerate mutase), ENO1 (enolase), PKM (pyruvate kinase M), and TPI1 (triosephosphate isomerase) are all canonical glycolytic enzymes, forming the clear core of this module. MTHFD2 links to one-carbon/folate metabolism supporting nucleotide synthesis. P4HB (protein disulfide isomerase), PSMA2 (proteasome subunit), ADRM1 (proteasome receptor), RAD23A (ubiquitin receptor), and UBE2N (ubiquitin-conjugating enzyme) reflect protein quality control/proteasome activity. CSNK2B, YWHAQ (14-3-3), POLR2E, NUTF2, TUFM round out general metabolic housekeeping. This is a glycolysis-centered metabolic module, consistent with activated/effector CD8 T cells relying on aerobic glycolysis.
Genes
ADRM1, CSNK2B, ENO1, MTHFD2, NUTF2, P4HB, PGAM1, PKM, POLR2E, PSMA2, RAD23A, TPI1, TUFM, UBE2N, YWHAQ
Most correlated modules
- RNA Splicing Complex · correlation 0.95
- Mitochondrial Metabolism · correlation 0.95
- Cellular Housekeeping · correlation 0.95
- Rho GTPase Cytoskeletal · correlation 0.94
- Mitochondrial ETC/OxPhos · correlation 0.94
- RNA & Redox Housekeeping · correlation 0.93
- Vesicle Trafficking · correlation 0.93
- mRNA Stability/Processing · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.