Mitochondrial ETC/OxPhos
Gene co-expression module in CD8⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub gene UQCRQ is a subunit of mitochondrial complex III, and NDUFS8, NDUFA11, NDUFB11 are Complex I subunits, COX6A1 is a Complex IV subunit — together these form a clear oxidative phosphorylation/mitochondrial electron transport chain signature. Additional genes include MRPL23 (mitochondrial ribosomal protein), HSD17B10 (mitochondrial enzyme), and SUMO2/BAX (stress/apoptosis-related but broadly expressed). LSM2, RALY, ERH are RNA processing genes that may co-vary due to general metabolic activity. AP2S1 is a clathrin adaptor. The module is dominated by mitochondrial respiratory chain components, all uniformly expressed, consistent with a housekeeping mitochondrial OxPhos program in CD8 T cells.
Genes
AP2S1, BAX, COX6A1, ERH, HSD17B10, LSM2, MAD2L2, MEA1, MRPL23, NAA38, NDUFA11, NDUFB11, NDUFS8, RALY, SUMO2, UQCRQ
Most correlated modules
- General Housekeeping · correlation 0.96
- Rho GTPase Cytoskeletal · correlation 0.95
- Cellular Housekeeping · correlation 0.95
- Cellular Housekeeping · correlation 0.94
- Glycolysis Program · correlation 0.94
- Mitochondrial Metabolism · correlation 0.94
- Mitochondrial OxPhos · correlation 0.93
- Proteasome Degradation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.