C19ORF53 — Chromosome 19 open reading frame 53

C19ORF53 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

C19ORF53's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ATP5F1E, ATP5MC2, COX7A2, EDF1, OST4, SRP14, TMA7, UQCR11	View in SCUBA
CD4⁺ T cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ANP32B, ATP5MC2, COX7C, EIF3H, EIF3M, EMC7, GPX4, HINT1 +10 more	View in SCUBA
CD8⁺ T cells	mRNA Stability/Processing RNA processing & translation	EDF1, GPX4, HNRNPA0, IMPDH2, NAP1L1, NHP2, PTMA, YBX1	View in SCUBA
Fibroblasts	General Housekeeping Housekeeping	ATP6V0E1, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A, SNU13 +4 more	View in SCUBA
Gamma-delta T cells	Electron Transport Chain Mitochondrial & OxPhos	ARL6IP4, BBLN, COX5B, COX7A2, MIF, NDUFA4, NDUFB4, NME2 +6 more
Glial cells	Proteostasis Stress Response Stress	ATOX1, ATP5MG, ATP6V0E1, C4orf3, COX7B, CYSTM1, GUK1, IFITM2 +7 more	View in SCUBA
Innate lymphoid cells	ILC-1 identity Differentiation	ABRACL, BLOC1S1, CD52, DAD1, FUCA2, GMFG, HMGN3, ISCU +20 more	View in SCUBA
Macrophages	Proteasome UPS Housekeeping	ACP1, ARPC5L, ATP6V1G1, AURKAIP1, CHMP2A, CIAO2B, CIB1, COPE +31 more	View in SCUBA
Smooth muscle cells	Respiratory Chain Subunits Mitochondrial & OxPhos	COX6A1, COX7B, MZT2B, NDUFB1, PFN1, SNRPD2, SNX3, UBXN1 +2 more	View in SCUBA

About the gene

Synonyms	HSPC023, LYDG10
Chromosome	19: 13774456-13778773
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins

Function

May have a potential role in hypercalcemia of malignancy

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.