Translation Elongation
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes RACK1, EEF2, EEF1A1, EEF1D (translation elongation factors), EIF3E (translation initiation factor), PFDN5 (prefoldin chaperone for cytoskeletal proteins), TOMM7 (mitochondrial outer membrane translocase) constitute a core translational machinery module. VSIR (VISTA, an immune checkpoint receptor) and NDFIP1 (Nedd4 family interacting protein, involved in immune regulation/ubiquitination) are also present. The dominant signal is active protein synthesis machinery, consistent with a housekeeping translation program in actively protein-synthesizing CD8 T cells. VSIR as a peripheral member may reflect immune regulatory context. High mean expression (2.411) and 66% detection support a broadly active housekeeping program.
Genes
EEF1A1, EEF1D, EEF2, EIF3E, NDFIP1, PFDN5, RACK1, TOMM7, VSIR
Most correlated modules
- Ribosome Biogenesis · correlation 0.68
- Naive/Central Memory · correlation 0.57
- Naive/Memory CD8 · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.