VSIR — V-set immunoregulatory receptor

VSIR belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

VSIR's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Tissue-resident memory B B cell maturation	CALHM2, CCR1, CMTM7, FCRL4, FGD4, GSN, ITGB7, PIK3R6 +4 more	View in SCUBA
CD8⁺ T cells	Translation Elongation RNA processing & translation	EEF1A1, EEF1D, EEF2, EIF3E, NDFIP1, PFDN5, RACK1, TOMM7	View in SCUBA
Endothelial	Venous Endothelial Identity Endothelial cell development	ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B +11 more	View in SCUBA
Gamma-delta T cells	Coinhibitory Checkpoint Exhaustion	BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more
Hematopoietic progenitor cells	Myeloid Commitment Myeloid development	ADA, ALDH2, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1 +4 more
Macrophages	Lysosomal Hydrolase Program Lysosomal & pahgocytosis	AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more	View in SCUBA
Mucosal-associated invariant T cell	MAIT Effector Maturation T cell maturation	ASF1A, BET1, CRYZ, DAXX, ECI2, EOMES, FNTA, IRF3 +10 more
Smooth muscle cells	Pericyte Basement Membrane ECM remodeling	ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more	View in SCUBA

About the gene

Synonyms	B7-H5, B7H5, C10orf54, Dies1, GI24, PD-1H, SISP1, VISTA
Chromosome	10: 71747556-71773520
Predicted location	Membrane
Essential gene	No
Protein class	Predicted membrane proteins
Molecular function	Receptor

Function

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14- mediated MMP2 activation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.