SCUBA

EEF1A1 — Eukaryotic translation elongation factor 1 alpha 1

EEF1A1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EEF1A1's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsTranslation Elongation
RNA processing & translation		EEF1D, EEF2, EIF3E, NDFIP1, PFDN5, RACK1, TOMM7, VSIRView in SCUBA
EndothelialTranslation Elongation
RNA processing & translation		CCNI, COMMD6, EEF1B2, EEF2, EIF3F, EIF3L, EIF4B, FBL +7 moreView in SCUBA
EnterocytesTranslation Elongation
RNA processing & translation		ATP5F1E, ATP5MC2, BTF3, EEF1B2, EIF3E, NACA, NDUFC2, PFDN5 +5 moreView in SCUBA
Gamma-delta T cellsRedox Stress Response
Stress		BEX2, BEX4, CITED4, FMNL3, FTL, GRINA, LTBP3, MICAL1 +5 more
Glial cellsNascent Polypeptide Translation
RNA processing & translation		BTF3, EIF3K, ERH, FAU, LGALS3, NACA, NDUFA4, RACK1 +2 moreView in SCUBA
Goblet cellsmRNA Translation Initiation
RNA processing & translation		EEF1B2, EIF3D, EIF3E, EIF3F, EIF3L, PABPC1, RACK1, SLC25A6 +2 moreView in SCUBA
Innate lymphoid cellsSUMOylation Program
Protein processing & ER		ATP5MG, ATP6V1G1, BTF3, C4orf3, COX7C, EDF1, HINT1, OSTC +5 moreView in SCUBA
Lymphatic endothelialTranslation Elongation
RNA processing & translation		ANXA2, EEF2, EIF1, FTH1, FTL, HNRNPA0, HNRNPA1, PTMA +2 moreView in SCUBA
Natural Killer cellsTranslation Elongation
RNA processing & translation		BTF3, COMMD6, EEF1B2, EEF1D, EIF3E, NACA, NOP53, PFDN5 +3 moreView in SCUBA
NeutrophilsTranslational Housekeeping
Housekeeping		COX4I1, EEF1B2, GSTP1, MGST1, NPM1, RACK1, UBA52, YBX1
Smooth muscle cellsTranslation elongation housekeeping
Housekeeping		COX4I1, EEF1D, EEF2, FTH1, FTL, GAPDH, PTMA, RACK1 +4 moreView in SCUBA

About the gene

SynonymsEE1A1, EEF1A, EF1A, EF1A1, EF1alpha1, LENG7
Chromosome6: 73489308-73525587
Predicted locationIntracellular
Essential geneYes
Protein classCancer-related genes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionElongation factor, Hydrolase
Biological processHost-virus interaction, Protein biosynthesis, Transcription, Transcription regulation

Function

Translation elongation factor that catalyzes the GTP- dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity). (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.