Naive/Memory CD8
Gene co-expression module in CD8⁺ T cells
| Category | T cell maturation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes TPT1 (translation regulator/survival factor), EEF1B2 and NACA (translation elongation/nascent chain), IL7R (naive/memory T cell survival cytokine receptor), CD48 (T cell activation co-receptor), MATK (lymphocyte kinase), MYBL1 (transcription factor in lymphocytes), CD55 (complement regulatory protein), PTGER2 (prostaglandin receptor) collectively point to a naive/central memory CD8 T cell program with active translational machinery and survival signaling. IL7R and MYBL1 are classical markers of naive/stem-like memory T cells. The module is core-coherent and uniformly expressed, consistent with a baseline housekeeping-plus-memory T cell identity program rather than a stress or activation response.
Genes
C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MATK, MYBL1, NACA, NCF1, PTGER2, TPT1
Most correlated modules
- Naive/Central Memory · correlation 0.65
- AP-1 Early Activation · correlation 0.57
- Translation Elongation · correlation 0.55
- Effector Memory CD8 · correlation 0.46
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.