Ribosome Biogenesis
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
FBL (fibrillarin) is a core nucleolar protein involved in rRNA processing and ribosome biogenesis. NPM1 (nucleophosmin) is a nucleolar chaperone central to ribosome biogenesis and rRNA processing. EIF3H and EIF3L are subunits of eukaryotic initiation factor 3, driving mRNA translation initiation. PABPC1 is a poly(A)-binding protein regulating mRNA stability and translation. BTF3 is a transcription/translation-associated factor. UXT is a ubiquitous expressed transcript involved in transcriptional regulation. FXYD5 is a membrane protein. NOSIP modulates eNOS but is broadly expressed. SMDT1 is a mitochondrial inner membrane protein. ERP29 is an ER luminal protein. S100A10, LTB, LDHB, CCND3, TMEM123 are peripheral members. The core of this module (FBL, NPM1, EIF3H, EIF3L, PABPC1, BTF3) points clearly to an RNA processing and translation initiation program, likely reflecting a housekeeping biosynthetic state. The neighbor M56 is a chaperone/stress module, consistent with shared upstream biosynthetic/proteostasis regulation.
Genes
BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB, LTB, NOSIP, NPM1, PABPC1, S100A10, SMDT1, TMEM123, TXK, UXT
Most correlated modules
- Translation Elongation · correlation 0.68
- Naive/Central Memory · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.