SCUBA

TOMM7 — Translocase of outer mitochondrial membrane 7

TOMM7 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TOMM7's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsTranslation Elongation
RNA processing & translation
EEF1A1, EEF1D, EEF2, EIF3E, NDFIP1, PFDN5, RACK1, VSIRView in SCUBA
EnterocytesTranslation Elongation
RNA processing & translation
ATP5F1E, ATP5MC2, BTF3, EEF1A1, EEF1B2, EIF3E, NACA, NDUFC2 +5 moreView in SCUBA
Gamma-delta T cellsTranslation Initiation
RNA processing & translation
BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more
Goblet cellsCo-translational Chaperone
Protein processing & ER
ATP5MC2, BTF3, COMMD6, FTH1, FTL, HIGD2A, NACA, PFDN5View in SCUBA
Innate lymphoid cellsProtein Biogenesis & Import
Protein processing & ER
ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5 +6 moreView in SCUBA
Lymphatic endothelialOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5F1D, ATP5F1E, ATP5MC2, ATP5ME, ATP5MG, COMMD6, COX7C, EIF3K +3 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos
ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 moreView in SCUBA
Natural Killer cellsTranslation Elongation
RNA processing & translation
BTF3, COMMD6, EEF1A1, EEF1B2, EEF1D, EIF3E, NACA, NOP53 +3 moreView in SCUBA
Smooth muscle cellsTranslation elongation housekeeping
Housekeeping
COX4I1, EEF1A1, EEF1D, EEF2, FTH1, FTL, GAPDH, PTMA +4 moreView in SCUBA

About the gene

SynonymsTom7
Chromosome7: 22812628-22822849
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins
Biological processProtein transport, Transport

Function

Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.