PFDN5 — Prefoldin subunit 5

PFDN5 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PFDN5's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Translation Elongation RNA processing & translation	EEF1A1, EEF1D, EEF2, EIF3E, NDFIP1, RACK1, TOMM7, VSIR	View in SCUBA
Endothelial	Translation Elongation RNA processing & translation	CCNI, COMMD6, EEF1A1, EEF1B2, EEF2, EIF3F, EIF3L, EIF4B +7 more	View in SCUBA
Enterocytes	Translation Elongation RNA processing & translation	ATP5F1E, ATP5MC2, BTF3, EEF1A1, EEF1B2, EIF3E, NACA, NDUFC2 +5 more	View in SCUBA
Gamma-delta T cells	Translation Initiation RNA processing & translation	BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more
Glial cells	RNA Translation Processing RNA processing & translation	CYCS, EEF1B2, EEF1D, HNRNPA1, HNRNPH3, LDHA, NAP1L1, NPM1 +5 more	View in SCUBA
Goblet cells	Co-translational Chaperone Protein processing & ER	ATP5MC2, BTF3, COMMD6, FTH1, FTL, HIGD2A, NACA, TOMM7	View in SCUBA
Innate lymphoid cells	Protein Biogenesis & Import Protein processing & ER	ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, S100A4 +6 more	View in SCUBA
Lymphatic endothelial	Protein Quality Control Protein processing & ER	BCAP29, CD99, CDC42, DYNLRB1, GNG5, NDUFV2, PDCD6, SKP1 +1 more	View in SCUBA
Macrophages	Mitochondrial OXPHOS Mitochondrial & OxPhos	APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB +28 more	View in SCUBA
Mucosal-associated invariant T cell	Translation Elongation RNA processing & translation	BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, FTL +8 more
Natural Killer cells	Translation Elongation RNA processing & translation	BTF3, COMMD6, EEF1A1, EEF1B2, EEF1D, EIF3E, NACA, NOP53 +3 more	View in SCUBA
Smooth muscle cells	Ubiquitous Housekeeping Transcripts Housekeeping	ATP6V1G1, C12orf57, CIRBP, FIS1, GSTP1, ISCU, NDUFB8, NUPR1 +3 more	View in SCUBA

About the gene

Synonyms	MM-1, PFD5
Chromosome	12: 53295291-53299452
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Chaperone

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.