Glucocorticoid Stress Response
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes: EIF4A1 (translation initiation helicase), ISG20L2 (ISG20-like, rRNA processing/nucleolar), TUT7 (terminal uridylyl transferase, RNA decay), ZC3HAV1 (zinc finger antiviral protein, RNA surveillance), MCOLN1 (mucolipin-1, lysosomal calcium channel), STK17B (DRAK2, apoptosis-regulating kinase), TSC22D3 (GILZ, glucocorticoid-induced leucine zipper — anti-inflammatory/tolerance), DDIT3 (CHOP, ER stress/integrated stress response), SLC3A2 (amino acid transporter, mTOR/stress), SMCHD1 (chromatin), ADGRE5 (CD97, adhesion GPCR), NXT1 (nuclear export). TSC22D3/GILZ is a well-known glucocorticoid response gene associated with tolerance and anti-inflammatory signaling. DDIT3/CHOP links to integrated stress response. The treatment response (delta_treatment_post_pre = -0.089) suggests this module decreases with treatment. The combination of GILZ, DDIT3, and stress-response genes suggests a glucocorticoid/integrated stress response program. EIF4A1 and ISG20L2 may reflect translational stress adaptation.
Genes
Most correlated modules
- p53 Transcriptional Regulation · correlation 0.93
- AP-1 cDC2 Activation · correlation 0.88
- Immediate Early Response · correlation 0.88
- Proliferating DC Program · correlation 0.87
- DC Proliferation Program · correlation 0.87
- mRNA Splicing · correlation 0.85
- Golgi-Endosomal Trafficking · correlation 0.84
- RNA Splicing Processing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.