Metabolic Housekeeping
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
The module is moderately coherent with low mean expression (~20% detection). Hub genes include NDUFA5 (mitochondrial complex I subunit), ECI2 (fatty acid beta-oxidation), ACAA2 (fatty acid beta-oxidation), PSMD3 (proteasome), CSE1L (nuclear export/proliferation), ATP2A3 (SERCA calcium pump), VPS26B (retromer complex), UPF3A (nonsense-mediated decay), DCPS (mRNA decapping), and CTCF (chromatin organizer). Several genes are enriched in prolif_DC (CSE1L 3.3x, ATP2A3 2.9x, ACAA2 2.5x, MYL6B 2.3x, NUDCD2 2.0x, DCPS 2.0x), suggesting a proliferating DC bias. The module mixes housekeeping metabolic functions (mitochondrial, fatty acid oxidation, proteasome, RNA quality control) without a single dominant pathway. The moderate coherence and mixed membership scores confirm this is a blended housekeeping/metabolic module. Neighbor context: M72 and M118 also contain mitochondrial/metabolic and proteasome genes, suggesting a neighborhood of general metabolic housekeeping programs. The prolif_DC enrichment of several genes may reflect higher metabolic activity in proliferating cells rather than a proliferation-specific program per se.
Genes
Most correlated modules
- Endocytic Vesicular Trafficking · correlation 0.95
- DNA Replication Chromatin · correlation 0.93
- DC Proliferation · correlation 0.92
- Mitochondrial OxPhos · correlation 0.92
- Spliceosome RNA Processing · correlation 0.92
- Ribosome Biogenesis · correlation 0.92
- Mitochondrial Biogenesis · correlation 0.92
- MYC-driven Proliferation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.