MYC-driven Proliferation
Gene co-expression module in Dendritic cells
| Category | Proliferation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub MYCBP (MYC-binding protein) anchors a MYC-driven proliferative biosynthesis program. Supporting genes include SMC3 (cohesin subunit, DNA replication), NUP210 (nuclear pore, cell growth), MRPS26 (mitochondrial ribosomal protein), PSMG3 (proteasome assembly chaperone), PMVK (mevalonate kinase, sterol biosynthesis), SAMD1 (chromatin regulation), and STOML2 (mitochondrial inner membrane). The module is strongly enriched in prolif_DC and neighbors M61 and M56, all sharing a proliferating DC co-expression neighborhood. MYCBP-driven transcription supports anabolic biosynthesis during cell growth.
Genes
Most correlated modules
- Endocytic Vesicular Trafficking · correlation 0.94
- Mitotic Proliferation · correlation 0.94
- Ribosome Biogenesis · correlation 0.93
- Metabolic Housekeeping · correlation 0.93
- Mitochondrial OxPhos · correlation 0.92
- Vesicular Housekeeping · correlation 0.91
- DNA Replication Chromatin · correlation 0.91
- Metabolic Housekeeping · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.