Mitochondrial OxPhos
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial OxPhos components: NDUFB9 (Complex I), ETFB (electron transfer flavoprotein), ATP5IF1 (ATP synthase inhibitor factor), AIFM1 (mitochondrial apoptosis-inducing factor), PTPMT1 (mitochondrial phosphatase), and MRPL48 (mitochondrial ribosomal protein). BRI3BP links to mitochondrial/apoptotic signaling. POLE3 and DCK add a DNA synthesis flavor consistent with the prolif_DC enrichment context. The module is strongly coherent and predominantly represents mitochondrial respiratory chain activity co-expressed in proliferating DCs.
Genes
Most correlated modules
- Spliceosome RNA Processing · correlation 0.95
- Vesicular Housekeeping · correlation 0.93
- Endocytic Vesicular Trafficking · correlation 0.93
- MYC-driven Proliferation · correlation 0.92
- Metabolic Housekeeping · correlation 0.92
- Mitotic Proliferation · correlation 0.91
- DC Proliferation · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.