p53 Transcriptional Regulation
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes MDM4 (negative regulator of p53), ATM (DNA damage kinase that phosphorylates p53), and EP300 (p53 coactivator/HAT) form a coherent p53 pathway regulatory axis. CCNT1 (Cyclin T1, CDK9 partner for transcriptional elongation), HNRNPUL1 (RNA processing), SETDB2 (H3K9 methyltransferase, epigenetic silencing), ZFP36L2 (mRNA decay factor), CITED2 (transcriptional coactivator), and ERN1 (IRE1α, UPR sensor) add layers of transcriptional and post-transcriptional regulation. AKAP9 and MAPRE2 are scaffolding/cytoskeletal regulators. The module is uniformly expressed with no significant inflammation response, suggesting a constitutive transcriptional regulatory program. The p53/MDM4/ATM axis is the clearest anchor.
Genes
Most correlated modules
- Glucocorticoid Stress Response · correlation 0.93
- AP-1 cDC2 Activation · correlation 0.92
- Proliferating DC Program · correlation 0.91
- Immediate Early Response · correlation 0.88
- RNA Splicing Processing · correlation 0.86
- Transcriptional Homeostasis · correlation 0.85
- Tolerogenic Lipid Metabolism · correlation 0.85
- cDC2 CLR Signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.