BMP/SMAD target genes
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
The hubs are canonical BMP/SMAD targets: ID1, ID2 and ID3 with the feedback regulators SMAD7 and SMAD9, plus CDKN1A for postmitotic arrest. Together they mark a luminal BMP-responsive state known to drive EEC hormone switching. The module is spread at similar folds across EC, INSL5, N and I cells, consistent with a positional state that crosses subsets rather than contamination.
Genes
Most correlated modules
- Surface hypoxic state · correlation 0.87
- Secretin/epithelial co-program · correlation 0.81
- CALCR/CDHR3 EC program · correlation 0.78
- RXFP4+ EC signature · correlation 0.76
- GATA2/SMAD6 regulators · correlation 0.76
- EC membrane receptors · correlation 0.71
- NPW terminal maturation · correlation 0.67
- Serotonin biosynthesis · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.