RXFP4+ EC signature
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
All seven genes are core members and peak in EC cells (RXFP4 15.1x, SMOC1 9.1x, DNER 7.7x, F5 6.6x), defining a tightly co-regulated enterochromaffin-specific signature. It is led by the INSL5 receptor RXFP4 and by the EC-subset-enriched genes SMOC1 and DNER. The colonocyte and endothelial annotations on SPAG1 and CD59 reflect genuine localized expression in EC cells, not contamination.
Genes
Most correlated modules
- NAT8L/APOD EC subset · correlation 0.91
- Serotonin biosynthesis · correlation 0.88
- SV2C/KCNS3 EC program · correlation 0.86
- ADRA1B/SYNGR4 EC subset · correlation 0.83
- GATA2/SMAD6 regulators · correlation 0.82
- EC accessory genes · correlation 0.82
- SYT1/ATP6V1C2 vesicle genes · correlation 0.81
- EC membrane receptors · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.