EC membrane receptors
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Most hub genes peak in EC cells (IL6R, DTNA, NRP1 at 4-5x), forming an EC-enriched membrane receptor and scaffold program (NRP1, IL6R, DTNA, PLCH1, CPNE4) rather than contamination. Its correlation with the EC-cell RXFP4 signature and the NAT8L/APOD EC subset supports the EC assignment, although DMD and SLC16A5 lean toward I and INSL5 cells.
Genes
Most correlated modules
- EC accessory genes · correlation 0.81
- RXFP4+ EC signature · correlation 0.81
- NAT8L/APOD EC subset · correlation 0.80
- ADRA1B/SYNGR4 EC subset · correlation 0.76
- SYT1/ATP6V1C2 vesicle genes · correlation 0.75
- TF-defined EC subtype · correlation 0.74
- BMP/SMAD target genes · correlation 0.71
- SYT4+ vesicle state · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.