Secretin/epithelial co-program
Gene co-expression module in Enteroendocrine cells
| Category | I cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Secretin (SCT, 3.6–3.9x in I and N cells) co-varies with small-intestinal epithelial identity genes (CDH17, CDHR5, MUC13). I-cell-biased genes (GALK1 6.4x, PTGER4 3.3x, BDKRB2) indicate a proximal small-intestinal I/N-cell program rather than a pan-EEC one; LRP1 may partly reflect contamination.
Genes
Most correlated modules
- Villus enterocyte-like state · correlation 0.87
- NPW terminal maturation · correlation 0.87
- Surface hypoxic state · correlation 0.82
- BMP/SMAD target genes · correlation 0.81
- Small-intestinal absorptive signature · correlation 0.73
- Peptide tyrosine sulfation · correlation 0.73
- Villus EC subpopulation · correlation 0.70
- RARRES1/PCSK5 small-bowel program · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.