Villus enterocyte-like state
Gene co-expression module in Enteroendocrine cells
| Category | I cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 16 genes have a known function matching the annotation |
Why this annotation
Villus enterocyte and villus-tip genes (ANPEP, MEP1A, KRT20, FABP2, AMN, HOPX, ABCG2, NR1H4, CYP3A5) are localized to small-intestinal I and N cells, which mature high on the villus under BMP signaling (TBX3). Because the program is localized, it reads as a villus-zonated, enterocyte-like state of these subsets rather than spread contamination, although enterocyte doublets cannot be fully excluded.
Genes
Most correlated modules
- Secretin/epithelial co-program · correlation 0.87
- Small-intestinal absorptive signature · correlation 0.84
- Proximal regional identity · correlation 0.84
- Peptide tyrosine sulfation · correlation 0.83
- CDX2/HNF4G intestinal identity · correlation 0.81
- RARRES1/PCSK5 small-bowel program · correlation 0.80
- NPW terminal maturation · correlation 0.80
- Peptidergic neuronal-type genes · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.