Small-intestinal absorptive signature
Gene co-expression module in Enteroendocrine cells
| Category | I cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Core hub genes typical of small-intestinal villus enterocytes (PRAP1, MEP1B, BTNL8, MAF, NHERF1, TM4SF5, TMEM176A/B, GBP3) are enriched in the small-intestinal EEC subsets, highest in I cells and also in N and K cells. This points to a regional small-intestinal epithelial/absorptive identity program shared by these subsets, not a colonic one. Because the genes are 30–90x higher in enterocytes, ambient enterocyte RNA in small-intestine samples remains a plausible alternative explanation.
Genes
Most correlated modules
- RARRES1/PCSK5 small-bowel program · correlation 0.91
- CDX2/HNF4G intestinal identity · correlation 0.87
- Small-intestinal I/K-cell signature · correlation 0.84
- Villus enterocyte-like state · correlation 0.84
- Small-intestinal lipid metabolism · correlation 0.80
- Neurotensin N-cell Program · correlation 0.76
- NPW terminal maturation · correlation 0.74
- Secretin/epithelial co-program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.