CDX2/HNF4G intestinal identity
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Module hubs are intestinal epithelial identity genes, the transcription factors CDX2 and HNF4G plus small-bowel genes ENPEP, MALRD1, FAM3B, ABCB1 and GIPC2, enriched in the small-intestinal I, N and K subsets. The TF-driven identity content separates it from the RARRES1/PCSK5 small-bowel program, reflecting a genuine small-intestinal regional epithelial program in these EECs rather than contamination.
Genes
Most correlated modules
- RARRES1/PCSK5 small-bowel program · correlation 0.88
- Small-intestinal I/K-cell signature · correlation 0.88
- Small-intestinal nutrient metabolism · correlation 0.88
- Small-intestinal absorptive signature · correlation 0.87
- Villus enterocyte-like state · correlation 0.81
- Proximal MX/I-cell signature · correlation 0.76
- Peptidergic neuronal-type genes · correlation 0.73
- Rho-GEF cytoskeletal signaling · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.