Peptide tyrosine sulfation
Gene co-expression module in Enteroendocrine cells
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 2 of 8 genes have a known function matching the annotation |
Why this annotation
TPST2, the Golgi tyrosylprotein sulfotransferase that sulfates CCK and related peptide hormones, and the neuroendocrine-expressed FAM163A are enriched in small-intestinal I, K and N cells, pointing to a peptide-processing state of these subsets. The module is diluted by immune and goblet genes (C1QA, C1QB, CTSC, SPOCK2, BCAS1), and with only 8 genes of moderate coherence the label remains a best guess.
Genes
Most correlated modules
- Proximal regional identity · correlation 0.85
- Villus enterocyte-like state · correlation 0.83
- Villus EC subpopulation · correlation 0.76
- Peptidergic neuronal-type genes · correlation 0.73
- Secretin/epithelial co-program · correlation 0.73
- SCN3A/HCN1 EC excitability · correlation 0.73
- Small-intestinal lipid metabolism · correlation 0.72
- Small-intestinal nutrient metabolism · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.