Peptidergic neuronal-type genes
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
The neuronal-type hub genes FAM135B, SLC8A1 (a Na+/Ca2+ exchanger shaping secretory calcium handling), BRINP3, SNTG1 and FAM181B are enriched together at modest folds across peptidergic I, N, MX and K cells rather than EC cells. This points to a shared peptide-hormone lineage feature whose exact function is ambiguous, and HOXC9 likely reflects regional identity.
Genes
Most correlated modules
- Villus enterocyte-like state · correlation 0.78
- Proximal regional identity · correlation 0.76
- Peptide tyrosine sulfation · correlation 0.73
- CDX2/HNF4G intestinal identity · correlation 0.73
- Small-intestinal lipid metabolism · correlation 0.72
- Small-intestinal absorptive signature · correlation 0.71
- Small-intestinal nutrient metabolism · correlation 0.70
- Proximal MX/I-cell signature · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.