ADRA1B/SYNGR4 EC subset
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes are sharply restricted to a minority of EC cells and combine synaptic/neuronal genes (SYNGR4, SEZ6L, MDGA1, APLP1, KIF1A) with the adrenergic receptor ADRA1B, marking a neuron-like, adrenergically responsive EC subpopulation. Its strong correlation with the NAT8L/APOD EC subset and the EC-cell RXFP4 signature supports a genuine EC-subtype program; COL1A2 and ITM2A are localized to EC cells and are not contamination.
Genes
Most correlated modules
- EC accessory genes · correlation 0.88
- SYT4+ vesicle state · correlation 0.84
- RXFP4+ EC signature · correlation 0.83
- NAT8L/APOD EC subset · correlation 0.82
- SV2C/KCNS3 EC program · correlation 0.79
- TF-defined EC subtype · correlation 0.77
- FHL1/SCN8A EC state · correlation 0.76
- EC membrane receptors · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.