TF-defined EC subtype
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
All genes are sharply restricted to a fraction of EC cells (10–52% detection). The hubs are developmental TFs (GBX1, PAX9, RXRG, MAFA) together with synaptic and neuronal genes (ADAM23, CBLN2, GRIA3, TNR), defining a distinct EC subpopulation rather than the general serotonin program.
Genes
Most correlated modules
- EC accessory genes · correlation 0.94
- Synaptic scaffold/regulators · correlation 0.90
- Neuron-like excitability · correlation 0.88
- FHL1/SCN8A EC state · correlation 0.84
- CDH22/SPATA17 EC markers · correlation 0.83
- SYT1/ATP6V1C2 vesicle genes · correlation 0.82
- GULP1/PRDM16 EC genes · correlation 0.81
- NAT8L/APOD EC subset · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.