NAT8L/APOD EC subset
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
All eight core genes are sharply restricted to EC cells (NAT8L 228x, PSTPIP1 122x, APOD 98x, FSTL1 55x), so this is a genuine EC-cell subpopulation program rather than mesenchymal or myeloid contamination. It lacks TPH1/CHGA and correlates tightly with the EC-cell RXFP4 signature and the ADRA1B/SYNGR4 EC subset, which places it among EC subtype signatures rather than core 5-HT synthesis.
Genes
Most correlated modules
- EC accessory genes · correlation 0.93
- SYT1/ATP6V1C2 vesicle genes · correlation 0.93
- RXFP4+ EC signature · correlation 0.91
- SV2C/KCNS3 EC program · correlation 0.89
- FHL1/SCN8A EC state · correlation 0.86
- SYT4+ vesicle state · correlation 0.83
- ADRA1B/SYNGR4 EC subset · correlation 0.82
- GULP1/PRDM16 EC genes · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.