EC accessory genes
Gene co-expression module in Enteroendocrine cells
| Category | Enterochromaffin program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Nearly every gene is sharply restricted to EC cells, with hubs GLYATL3, BVES, STRA6, FGF13 and AOAH at 12–124x. This makes it a genuine EC-restricted program rather than myeloid contamination. It lacks TPH1/DDC, so it captures EC accessory genes rather than the serotonergic core. Its tight correlation with the SYT1/ATP6V1C2 vesicle genes supports EC identity.
Genes
Most correlated modules
- TF-defined EC subtype · correlation 0.94
- NAT8L/APOD EC subset · correlation 0.93
- SYT1/ATP6V1C2 vesicle genes · correlation 0.93
- FHL1/SCN8A EC state · correlation 0.92
- SV2C/KCNS3 EC program · correlation 0.91
- ADRA1B/SYNGR4 EC subset · correlation 0.88
- Synaptic scaffold/regulators · correlation 0.86
- GULP1/PRDM16 EC genes · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.