SMOC2/FOXA2 crypt state
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
The crypt stem/progenitor marker SMOC2, the crypt-base integrin ITGA6, FOXA2 and the early-EEC marker HEPACAM2 peak in pre_EEC and L cells. This indicates a crypt-proximal immature state that persists in L cells, and it correlates with LGR5/NUMBL immature state. Several members (LIPG, CA8, SLCO5A1) lack a clear progenitor link.
Genes
Most correlated modules
- WNT9A/L1TD1 pre-EEC state · correlation 0.78
- SOX4/MEX3A pre-EEC regulators · correlation 0.74
- HES6 progenitor commitment · correlation 0.70
- Chaperonin/MYC growth genes · correlation 0.69
- FGFRL1/VWC2 pre-EEC state · correlation 0.69
- Ribosome/translation machinery · correlation 0.68
- Crypt-positioned EEC state · correlation 0.67
- Progenitor hnRNP program · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.