Crypt-positioned EEC state
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
EPHB3 (a Wnt-driven crypt-base positional receptor), CXXC4 (a Wnt pathway regulator), and the stem/TA-typical IGFBP2, CD9 and MGST1 co-vary with TUBA1B, marking a crypt-positioned, less mature state in L cells, pre_EECs and K cells. Enrichment is modest and the module correlates strongly with L-cell CXC Chemokines, so it may instead reflect an L-cell substate; the label remains tentative.
Genes
Most correlated modules
- ELR+ chemokine secretion · correlation 0.77
- SMOC2/FOXA2 crypt state · correlation 0.67
- L-cell identity program · correlation 0.62
- Colonic L-cell identity · correlation 0.58
- Colonic INSL5+ L-cell · correlation 0.57
- L-cell VSTM2A program · correlation 0.52
- GLP-1/PYY hormone program · correlation 0.51
- ARX+ Peptidergic Lineage · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.