Progenitor hnRNP program
Gene co-expression module in Enteroendocrine cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
Hubs are hnRNPs (HNRNPA0, HNRNPAB), ILF2, prothymosin alpha (PTMA) and the mRNA-export factor ENY2, a biosynthetic RNA-processing program of immature cells peaking in pre_EEC. Its very tight correlation with HES6 progenitor commitment and the other pre_EEC biosynthetic modules confirms it as part of the EEC progenitor state rather than a generic housekeeping set.
Genes
Most correlated modules
- HES6 progenitor commitment · correlation 0.96
- Chaperonin/MYC growth genes · correlation 0.96
- Ribosome/translation machinery · correlation 0.94
- SOX4/MEX3A pre-EEC regulators · correlation 0.92
- Biosynthetic housekeeping machinery · correlation 0.90
- CDKN1C cycle-exit progenitor · correlation 0.85
- WNT9A/L1TD1 pre-EEC state · correlation 0.85
- NEUROG3+ endocrine progenitor · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.