Ribosome/translation machinery
Gene co-expression module in Enteroendocrine cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 16 of 21 genes have a known function matching the annotation |
Why this annotation
Hubs are ribosome biogenesis and nascent-chain/translation factors (NPM1, NSA2, C1QBP, BTF3, NACA, SRP14, RACK1), spliceosomal Sm proteins and OxPhos subunits. They are uniformly elevated about 2x in pre_EEC cells, marking the high biosynthetic, MYC-like growth state of EEC progenitors rather than a hormone program.
Genes
Most correlated modules
- Chaperonin/MYC growth genes · correlation 0.95
- Biosynthetic housekeeping machinery · correlation 0.95
- Progenitor hnRNP program · correlation 0.94
- HES6 progenitor commitment · correlation 0.93
- WNT9A/L1TD1 pre-EEC state · correlation 0.89
- CDKN1C cycle-exit progenitor · correlation 0.88
- Respiratory chain subunits · correlation 0.88
- SOX4/MEX3A pre-EEC regulators · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.