WNT9A/L1TD1 pre-EEC state
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Nearly every gene, including hubs KIF19, YPEL1, L1TD1, WNT9A and CRISPLD2, peaks in pre_EEC with spillover into MX_cell, mixing stem/progenitor-associated genes (L1TD1, WNT9A) with epithelial progenitor keratin and translation genes and no hormone genes. Its tight correlation with the HES6 progenitor commitment and SOX4/MEX3A pre-EEC regulator modules places it in the immature pre-hormonal state, though its gene content is heterogeneous.
Genes
Most correlated modules
- HES6 progenitor commitment · correlation 0.92
- SOX4/MEX3A pre-EEC regulators · correlation 0.92
- FGFRL1/VWC2 pre-EEC state · correlation 0.89
- Ribosome/translation machinery · correlation 0.89
- NEUROG3+ endocrine progenitor · correlation 0.89
- Chaperonin/MYC growth genes · correlation 0.86
- Progenitor hnRNP program · correlation 0.85
- CDKN1C cycle-exit progenitor · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.