Chaperonin/MYC growth genes
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 7 genes have a known function matching the annotation |
Why this annotation
All seven genes are core members peaking in pre_EEC: MYC-driven progenitor growth genes for chaperonin folding (CCT2, CCT6A), translation initiation (EIF4A1), RNA processing (HNRNPA1, RBM3), nucleotide synthesis (NME1) and microtubule dynamics (STMN1). Together they mark the high-biosynthesis state of immature EEC precursors emerging from stem/TA cells.
Genes
Most correlated modules
- Progenitor hnRNP program · correlation 0.96
- HES6 progenitor commitment · correlation 0.96
- Ribosome/translation machinery · correlation 0.95
- Biosynthetic housekeeping machinery · correlation 0.91
- CDKN1C cycle-exit progenitor · correlation 0.90
- SOX4/MEX3A pre-EEC regulators · correlation 0.90
- PAX4/NKX2-2 specification · correlation 0.88
- WNT9A/L1TD1 pre-EEC state · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.