HES6 progenitor commitment
Gene co-expression module in Enteroendocrine cells
| Category | EEC development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 18 of 21 genes have a known function matching the annotation |
Why this annotation
Every gene peaks in pre_EEC cells, with weaker expression in MX_cells. The hub HES6, a canonical NEUROG3-downstream EEC progenitor gene, sits with RCOR2, HMGB3, MEX3B, GPC2 and progenitor chromatin/proliferation genes, defining the early endocrine-committed progenitor state; the label names the HES6/Notch-commitment step that separates it from the SOX4/MEX3A pre-EEC regulators and the biosynthetic progenitor modules.
Genes
Most correlated modules
- SOX4/MEX3A pre-EEC regulators · correlation 0.97
- Progenitor hnRNP program · correlation 0.96
- Chaperonin/MYC growth genes · correlation 0.96
- Ribosome/translation machinery · correlation 0.93
- WNT9A/L1TD1 pre-EEC state · correlation 0.92
- CDKN1C cycle-exit progenitor · correlation 0.90
- NEUROG3+ endocrine progenitor · correlation 0.87
- Biosynthetic housekeeping machinery · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.